For double-sided, top-bound Wire-o brochures, when you open the brochure in front of you, you can choose how the 'reading direction' of the top-page would be. This is determined by the possible 180° rotation of the prints on the even pages.

In example '1 - Example of file without rotation of even pages', you see how the Wire-o brochure would look in case you would not rotate any of the pages.

In example '2 - Example of file with 180° rotation of even pages', you see how the Wire-o brochure would look in case you would rotate the prints 180° on all of the even pages (except for the last page, for that is the back cover).
See the 'Wire-o Brochures Print-File Info-Sheet' included in the Templates, for more help on this topic.